Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

A defining pathophysiological hallmark of Alzheimer’s disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard, brittle structures scattered throughout the hippocampus and cerebral cortex and are thought to cause hyperphosphorylat...

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Bibliographic Details
Main Authors: María Velasco-Estevez, Myrthe Mampay, Hervé Boutin, Aisling Chaney, Peter Warn, Andrew Sharp, Ellie Burgess, Emad Moeendarbary, Kumlesh K. Dev, Graham K. Sheridan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
amyloid plaques
astrocytes
dentate gyrus
mechanosensitive ion channel
Piezo1
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00332/full

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