Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation.
Protein synthesis is a highly efficient process and is under exacting control. Yet, the actual abundance of translation factors present in translating complexes and how these abundances change during the transit of a ribosome across an mRNA remains unknown. Using analytical ultracentrifugation with...
Main Authors: | Xin Wang, Wen Xi, Shaun Toomey, Yueh-Chin Chiang, Jiri Hasek, Thomas M Laue, Clyde L Denis |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4783044?pdf=render |
Similar Items
-
Identification of a 57S translation complex containing closed-loop factors and the 60S ribosome subunit
by: Clyde L. Denis, et al.
Published: (2018-07-01) -
Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments
by: Liana F Lareau, et al.
Published: (2014-05-01) -
Roles of Inter-subunit Bridges of the Ribosome in Translation Initiation and Elongation
by: Liu, Qi
Published: (2015) -
Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation
by: Ryuta Ishimura, et al.
Published: (2016-04-01) -
Two alternative conformations of mRNA in the human ribosome during elongation and termination of translation as revealed by EPR spectroscopy
by: Konstantin N. Bulygin, et al.
Published: (2021-01-01)