Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer.

Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer.

The serine/threonine kinase Aurora-A (Aur-A) is a proto-oncoprotein overexpressed in a wide range of human cancers. Overexpression of Aur-A is thought to be caused by gene amplification or mRNA overexpression. However, recent evidence revealed that the discrepancies between amplification of Aur-A an...

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Bibliographic Details
Main Authors: Shojiro Kitajima, Yasusei Kudo, Ikuko Ogawa, Masaaki Tatsuka, Hidehiko Kawai, Michele Pagano, Takashi Takata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1976594?pdf=render

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