A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles

A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles

Highlights 1. We developed a biochip for rapid assay based on the magneto-optical Cotton–Mouton (CM) effect of γ-Fe2O3@Au core/shell magnetic nanoparticles. 2. The easy and quick assay for detection of the spike glycoprotein S of SARS-CoV-2 was demonstrated, and whole process takes approximately 50 ...

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Bibliographic Details
Main Authors: Kuen-Lin Chen, Zih-Yan Yang, Chin-Wei Lin
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Nanobiotechnology
Subjects:
Biochip
Cotton–Mouton (CM) effect
Nanoparticles
SARS-CoV-2
COVID-19
Online Access:https://doi.org/10.1186/s12951-021-01030-z
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spelling doaj-4de512bbbf76447583e208e110fac7fc2021-10-03T11:43:14ZengBMCJournal of Nanobiotechnology1477-31552021-10-0119111110.1186/s12951-021-01030-zA magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticlesKuen-Lin Chen0Zih-Yan Yang1Chin-Wei Lin2Institute of Nanoscience, National Chung Hsing UniversityDepartment of Physics, National Chung Hsing UniversityGraduate Institute of Applied Physics, National Taiwan UniversityHighlights 1. We developed a biochip for rapid assay based on the magneto-optical Cotton–Mouton (CM) effect of γ-Fe2O3@Au core/shell magnetic nanoparticles. 2. The easy and quick assay for detection of the spike glycoprotein S of SARS-CoV-2 was demonstrated, and whole process takes approximately 50 min including 3 min for the CM rotation measurement with the detection limit of 0.27 ng/mL (3.4 pM). 3. This magneto-optical biochip we proposed can be easily modified to use as assays for other diseases.https://doi.org/10.1186/s12951-021-01030-zBiochipCotton–Mouton (CM) effectNanoparticlesSARS-CoV-2COVID-19
collection DOAJ
language English
format Article
sources DOAJ
author Kuen-Lin Chen
Zih-Yan Yang
Chin-Wei Lin
spellingShingle Kuen-Lin Chen
Zih-Yan Yang
Chin-Wei Lin
A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles
Journal of Nanobiotechnology
Biochip
Cotton–Mouton (CM) effect
Nanoparticles
SARS-CoV-2
COVID-19
author_facet Kuen-Lin Chen
Zih-Yan Yang
Chin-Wei Lin
author_sort Kuen-Lin Chen
title A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles
title_short A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles
title_full A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles
title_fullStr A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles
title_full_unstemmed A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles
title_sort magneto-optical biochip for rapid assay based on the cotton–mouton effect of γ-fe2o3@au core/shell nanoparticles
publisher BMC
series Journal of Nanobiotechnology
issn 1477-3155
publishDate 2021-10-01
description Highlights 1. We developed a biochip for rapid assay based on the magneto-optical Cotton–Mouton (CM) effect of γ-Fe2O3@Au core/shell magnetic nanoparticles. 2. The easy and quick assay for detection of the spike glycoprotein S of SARS-CoV-2 was demonstrated, and whole process takes approximately 50 min including 3 min for the CM rotation measurement with the detection limit of 0.27 ng/mL (3.4 pM). 3. This magneto-optical biochip we proposed can be easily modified to use as assays for other diseases.
topic Biochip
Cotton–Mouton (CM) effect
Nanoparticles
SARS-CoV-2
COVID-19
url https://doi.org/10.1186/s12951-021-01030-z
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