The Role of RNA Secondary Structure in Regulation of Gene Expression in Bacteria

The Role of RNA Secondary Structure in Regulation of Gene Expression in Bacteria

Due to the high exposition to changing environmental conditions, bacteria have developed many mechanisms enabling immediate adjustments of gene expression. In many cases, the required speed and plasticity of the response are provided by RNA-dependent regulatory mechanisms. This is possible due to th...

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Bibliographic Details
Main Authors: Agnieszka Chełkowska-Pauszek, Jan Grzegorz Kosiński, Klementyna Marciniak, Marta Wysocka, Kamilla Bąkowska-Żywicka, Marek Żywicki
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
RNA structure
regulation of gene expression
ncRNAs
riboswitches
bacterial sRNAs
Online Access:https://www.mdpi.com/1422-0067/22/15/7845
Description
Summary:Due to the high exposition to changing environmental conditions, bacteria have developed many mechanisms enabling immediate adjustments of gene expression. In many cases, the required speed and plasticity of the response are provided by RNA-dependent regulatory mechanisms. This is possible due to the very high dynamics and flexibility of an RNA structure, which provide the necessary sensitivity and specificity for efficient sensing and transduction of environmental signals. In this review, we will discuss the current knowledge about known bacterial regulatory mechanisms which rely on RNA structure. To better understand the structure-driven modulation of gene expression, we describe the basic theory on RNA structure folding and dynamics. Next, we present examples of multiple mechanisms employed by RNA regulators in the control of bacterial transcription and translation.
ISSN:1661-6596
1422-0067

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