Effect of Low-Dose Naloxone on Pain Severity and Side Effects of Opioids on Patients Undergoing Laparoscopic Cholecystectomy

• Main Authors: Karamollah Toolabi, Ali Moazamipur, Kasra Karvandian, Ahmad Reza Dehpour
• Format: Article
• Language: fas
• Published: Lorestan University of Medical Science 2018-04-01
• Series: Yafteh
• Subjects: naloxone; morphine; laparoscopic cholecystectomy; pain; vomiting
• Online Access: http://yafte.lums.ac.ir/browse.php?a_code=A-10-2143-1&slc_lang=en&sid=1

Background: Previous studies have assessed effect of naloxone on pain severity and side effects of opioids however, their results are inconsistent. Our study was design to determine effect of low-dose naloxone on pain, nausea, vomiting, pruritus and urine retention on patients undergoing laparoscopic cholecystectomy. Materials & Methods: In this study 60 patients who need laparoscopic cholecystectomy participated and divided into two groups: naloxone (0.25 mg/kg/h naloxone plus 20 mg/kg/h morphine) and placebo (20 mg/kg/h morphine). Patients were evaluated 2, 4, 8 and 16 h after surgery and severity of pain and side effects including nausea, vomiting, pruritus and urine retention were recorded by a nurse. Results: Prevalence of nausea, vomiting, pruritus and urine retention in naloxone group was significantly lower than placebo 2, 4, 8 and 16 h after surgery. There was no significant difference on pain severity between two groups. Conclusion: Our results indicated that naloxone administration significantly decreased side effects of opioid including nausea, vomiting, pruritus and urine retention with no effect on pain severity.