Evaluation of hydroxyurea genotoxicity in patients with sickle cell disease

ABSTRACT Objective To evaluate the induction of DNA damage in peripheral blood mononuclear cells of patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea. Methods The study subjects were divided into two groups: one group of 22 patients with sickle cell disease, SS and...

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Bibliographic Details
Main Authors: Emanuel Almeida Moreira de Oliveira, Kenia de Assis Boy, Ana Paula Pinho Santos, Carla da Silva Machado, Cibele Velloso-Rodrigues, Pâmela Souza Almeida Silva Gerheim, Leonardo Meneghin Mendonça
Format: Article
Language:English
Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein
Series:Einstein (São Paulo)
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000400210&lng=en&tlng=en