Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)

• Main Authors: Zhu L, Xie S, Yang C, Hua N, Wu Y, Wang L, Ni W, Tong X, Fei M, Wang S
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-07-01
• Series: Cancer Management and Research
• Subjects: mature t-and nk-cell lymphoma; gene mutation; next generation sequencing
• Online Access: https://www.dovepress.com/current-progress-in-investigating-mature-t--and-nk-cell-lymphoma-gene--peer-reviewed-fulltext-article-CMAR

Lifen Zhu,1,* Shufang Xie,1,2,* Chen Yang,1,3,* Nanni Hua,1,2 Yi Wu,4 Lei Wang,1 Wanmao Ni,1 Xiangmin Tong,1 Min Fei,5 Shibing Wang1 1Molecular diagnosis laboratory, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 2The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Clinical Medicine, Qingdao University, Qingdao, Shandong, People’s Republic of China; 4Phase I clinical research center, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 5Center of Health Management, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min FeiCenter of Health Management, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of ChinaEmail [e-mail] WangMolecular diagnosis laboratory, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of ChinaEmail [e-mail]: Despite efforts to abrogate the severe threat to life posed by the profound malignancy of mature natural killer/T-cell lymphoma (NKTCL), therapeutic advances still require further investigation of its inherent regulatory biochemical processes. Next-generation sequencing (NGS) is an increasingly developing gene detection technique, which has been widely used in lymphoma genetic research in recent years. Targeted therapy based on the above studies has also generated a series of advances, making genetic mutation a new research hotspot in lymphoma. Advances in NKTCL-related gene mutations are reviewed in this paper.Keywords: mature T-and NK-cell lymphoma, gene mutation, next generation sequencing