Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia

Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia

Abstract Two important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) preclinical rat model of PE exhibits both of these features. Moreover, RUPP and PE women have elevated vasoconstrictor peptide endothelin-1 (ET-1...

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Bibliographic Details
Main Authors: Mark W. Cunningham, Lorena M. Amaral, Nathan E. Campbell, Denise C. Cornelius, Tarek Ibrahim, Venkata Ramana Vaka, Babbette LaMarca
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Biology of Sex Differences
Online Access:https://doi.org/10.1186/s13293-020-00345-0

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