A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM).

A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM).

Dandy-Walker-like malformation (DWLM) is the result of aberrant brain development and mainly characterized by cerebellar hypoplasia. DWLM affected dogs display a non-progressive cerebellar ataxia. Several DWLM cases were recently observed in the Eurasier dog breed, which strongly suggested a monogen...

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Bibliographic Details
Main Authors: Martina Gerber, Andrea Fischer, Vidhya Jagannathan, Michaela Drögemüller, Cord Drögemüller, Martin J Schmidt, Filipa Bernardino, Eberhard Manz, Kaspar Matiasek, Kai Rentmeister, Tosso Leeb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4323105?pdf=render

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