Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting...

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Main Authors: Ricardo M. Gouveia, Guillaume Lepert, Suneel Gupta, Rajiv R. Mohan, Carl Paterson, Che J. Connon
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09331-6
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spelling doaj-4db489443ac3438cb327cb65509749c42021-05-11T11:50:24ZengNature Publishing GroupNature Communications2041-17232019-04-0110111710.1038/s41467-019-09331-6Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiationRicardo M. Gouveia0Guillaume Lepert1Suneel Gupta2Rajiv R. Mohan3Carl Paterson4Che J. Connon5Institute of Genetic Medicine, Newcastle University, International Centre for LifeThe Blackett Laboratory, Imperial College LondonHarry S. Truman Memorial Veterans HospitalHarry S. Truman Memorial Veterans HospitalThe Blackett Laboratory, Imperial College LondonInstitute of Genetic Medicine, Newcastle University, International Centre for LifeThe link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting in regeneration.https://doi.org/10.1038/s41467-019-09331-6
collection DOAJ
language English
format Article
sources DOAJ
author Ricardo M. Gouveia
Guillaume Lepert
Suneel Gupta
Rajiv R. Mohan
Carl Paterson
Che J. Connon
spellingShingle Ricardo M. Gouveia
Guillaume Lepert
Suneel Gupta
Rajiv R. Mohan
Carl Paterson
Che J. Connon
Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
Nature Communications
author_facet Ricardo M. Gouveia
Guillaume Lepert
Suneel Gupta
Rajiv R. Mohan
Carl Paterson
Che J. Connon
author_sort Ricardo M. Gouveia
title Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_short Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_full Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_fullStr Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_full_unstemmed Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_sort assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-04-01
description The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting in regeneration.
url https://doi.org/10.1038/s41467-019-09331-6
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AT suneelgupta assessmentofcornealsubstratebiomechanicsanditseffectonepithelialstemcellmaintenanceanddifferentiation
AT rajivrmohan assessmentofcornealsubstratebiomechanicsanditseffectonepithelialstemcellmaintenanceanddifferentiation
AT carlpaterson assessmentofcornealsubstratebiomechanicsanditseffectonepithelialstemcellmaintenanceanddifferentiation
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