Syntheses of Labeled Dimethyl Phthalate-D6

• Main Author: XU Zhong-jie;LU Wei-jing;SUN Wen;JIANG Zhe;LI Bing-yao;PAN Jie
• Format: Article
• Language: zho
• Published: Editorial Board of Journal of Isotopes 2014-02-01
• Series: Journal of Isotopes
• Subjects: stable isotope labeled dimethyl phthalate synthesis functional materials
• Online Access: http://www.tws.org.cn/CN/10.7538/tws.2014.27.02.0072

The synthesis of labeled standard dimethyl phthalate-D6，with CD3OD and benzene anhydride as raw materials by an efficient and no-dilution of isotopic enrichment method was presented, under the catalysis of condensing agent to generate dimethyl phthalate-D6。The yield of dimethyl phthalate-D6 was 88.0% based on CD3OD consumed．The product was confirmed by NMR and MS to be target compound．Its chemical purity was 99.0% and isotopic enrichment was 99.1 atom % D．The result showed that It could be used as internal standard in the field of food safety testing．