New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015

The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1−21), including two new alkaloids (1 and 2) and one new pyrone derivative (<b&...

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Main Authors:	Xiaoyan Pang, Guodi Cai, Xiuping Lin, Limbadri Salendra, Xuefeng Zhou, Bin Yang, Junjian Wang, Junfeng Wang, Shihai Xu, Yonghong Liu
Format:	Article
Language:	English
Published:	MDPI AG 2019-07-01
Series:	Marine Drugs
Subjects:	sponge-derived fungus <i>Penicillium</i> sp. alkaloid X-ray single crystal diffraction antibacterial cytotoxic activity
Online Access:	https://www.mdpi.com/1660-3397/17/7/398

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spelling	doaj-4daa7842a521473fb9b8e46bfe9bf5bd2020-11-25T02:33:12ZengMDPI AGMarine Drugs1660-33972019-07-0117739810.3390/md17070398md17070398New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015Xiaoyan Pang0Guodi Cai1Xiuping Lin2Limbadri Salendra3Xuefeng Zhou4Bin Yang5Junjian Wang6Junfeng Wang7Shihai Xu8Yonghong Liu9College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCollege of Chemistry and Materials Science, Jinan University, Guangzhou 510632, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaThe sponge-derived fungus <i>Penicillium</i> sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (<b>1</b>−<b>21</b>), including two new alkaloids (<b>1</b> and <b>2</b>) and one new pyrone derivative (<b>3</b>). Their structures were elucidated by analysis of 1D/2D NMR data and HR−ESI−MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound <b>16</b> exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC<sub>50</sub> value of 5.19 μM. Compounds <b>9</b> and <b>18</b> showed weak antibacterial activity against <i>Staphylococcus aureus</i> and <i>Acinetobacter baumannii,</i> respectively, both with MIC values of 57 μg/mL. Furthermore, compound <b>16</b> displayed potent antibacterial activity against <i>S. aureus</i> with an MIC value of 3.75 μg/mL.https://www.mdpi.com/1660-3397/17/7/398sponge-derived fungus<i>Penicillium</i> sp.alkaloidX-ray single crystal diffractionantibacterialcytotoxic activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaoyan Pang Guodi Cai Xiuping Lin Limbadri Salendra Xuefeng Zhou Bin Yang Junjian Wang Junfeng Wang Shihai Xu Yonghong Liu
spellingShingle	Xiaoyan Pang Guodi Cai Xiuping Lin Limbadri Salendra Xuefeng Zhou Bin Yang Junjian Wang Junfeng Wang Shihai Xu Yonghong Liu New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015 Marine Drugs sponge-derived fungus <i>Penicillium</i> sp. alkaloid X-ray single crystal diffraction antibacterial cytotoxic activity
author_facet	Xiaoyan Pang Guodi Cai Xiuping Lin Limbadri Salendra Xuefeng Zhou Bin Yang Junjian Wang Junfeng Wang Shihai Xu Yonghong Liu
author_sort	Xiaoyan Pang
title	New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015
title_short	New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015
title_full	New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015
title_fullStr	New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015
title_full_unstemmed	New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015
title_sort	new alkaloids and polyketides from the marine sponge-derived fungus <i>penicillium</i> sp. scsio41015
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2019-07-01
description	The sponge-derived fungus <i>Penicillium</i> sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (<b>1</b>−<b>21</b>), including two new alkaloids (<b>1</b> and <b>2</b>) and one new pyrone derivative (<b>3</b>). Their structures were elucidated by analysis of 1D/2D NMR data and HR−ESI−MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound <b>16</b> exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC<sub>50</sub> value of 5.19 μM. Compounds <b>9</b> and <b>18</b> showed weak antibacterial activity against <i>Staphylococcus aureus</i> and <i>Acinetobacter baumannii,</i> respectively, both with MIC values of 57 μg/mL. Furthermore, compound <b>16</b> displayed potent antibacterial activity against <i>S. aureus</i> with an MIC value of 3.75 μg/mL.
topic	sponge-derived fungus <i>Penicillium</i> sp. alkaloid X-ray single crystal diffraction antibacterial cytotoxic activity
url	https://www.mdpi.com/1660-3397/17/7/398
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New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus <i>Penicillium</i> sp. SCSIO41015

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