Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by significant neuronal loss in the experimental autoim...
Main Authors: | Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/18246 |
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