In vitro inhibition of human influenza A virus replication by chloroquine

In vitro inhibition of human influenza A virus replication by chloroquine

<p>Abstract</p> <p>Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of...

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Main Authors: Loh Jin, Chew Janet, Ooi Eng, Chua Robert CS
Format: Article
Language:English
Published: BMC 2006-05-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/3/1/39
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spelling doaj-4da49ed83d6f4d108a694f42b32b2f312020-11-24T20:57:13ZengBMCVirology Journal1743-422X2006-05-01313910.1186/1743-422X-3-39In vitro inhibition of human influenza A virus replication by chloroquineLoh JinChew JanetOoi EngChua Robert CS<p>Abstract</p> <p>Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.</p> http://www.virologyj.com/content/3/1/39
collection DOAJ
language English
format Article
sources DOAJ
author Loh Jin
Chew Janet
Ooi Eng
Chua Robert CS
spellingShingle Loh Jin
Chew Janet
Ooi Eng
Chua Robert CS
In vitro inhibition of human influenza A virus replication by chloroquine
Virology Journal
author_facet Loh Jin
Chew Janet
Ooi Eng
Chua Robert CS
author_sort Loh Jin
title In vitro inhibition of human influenza A virus replication by chloroquine
title_short In vitro inhibition of human influenza A virus replication by chloroquine
title_full In vitro inhibition of human influenza A virus replication by chloroquine
title_fullStr In vitro inhibition of human influenza A virus replication by chloroquine
title_full_unstemmed In vitro inhibition of human influenza A virus replication by chloroquine
title_sort in vitro inhibition of human influenza a virus replication by chloroquine
publisher BMC
series Virology Journal
issn 1743-422X
publishDate 2006-05-01
description <p>Abstract</p> <p>Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.</p>
url http://www.virologyj.com/content/3/1/39
work_keys_str_mv AT lohjin invitroinhibitionofhumaninfluenzaavirusreplicationbychloroquine
AT chewjanet invitroinhibitionofhumaninfluenzaavirusreplicationbychloroquine
AT ooieng invitroinhibitionofhumaninfluenzaavirusreplicationbychloroquine
AT chuarobertcs invitroinhibitionofhumaninfluenzaavirusreplicationbychloroquine
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