Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf]
Out-of-the-box approaches are currently needed to replenish the souring pipelines of pharmaceutical companies across the globe. Here a theme is presented – the use of central nervous system (CNS) drugs as leads for non-CNS targets. The approach is related to the use of existing drugs for new indicat...
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| Online Access: | http://f1000research.com/articles/3-40/v1 |
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doaj-4d9d09049dfa404b9f41f846ac8de3832020-11-25T03:59:13ZengF1000 Research LtdF1000Research2046-14022014-02-01310.12688/f1000research.3-40.v13759Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf]Prashant S. Kharkar0Department of Pharmaceutical Chemistry, SPP School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai, 400056, IndiaOut-of-the-box approaches are currently needed to replenish the souring pipelines of pharmaceutical companies across the globe. Here a theme is presented – the use of central nervous system (CNS) drugs as leads for non-CNS targets. The approach is related to the use of existing drugs for new indications. Suitable chemical modifications of the CNS drugs abolish their CNS penetration. These novel analogs may then be screened for activity against non-CNS targets. Careful selection of the appropriate structural modifications remains the key to success.http://f1000research.com/articles/3-40/v1Drug Discovery & DesignNeuropharmacology & PsychopharmacologySmall Molecule Chemistry |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Prashant S. Kharkar |
| spellingShingle |
Prashant S. Kharkar Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf] F1000Research Drug Discovery & Design Neuropharmacology & Psychopharmacology Small Molecule Chemistry |
| author_facet |
Prashant S. Kharkar |
| author_sort |
Prashant S. Kharkar |
| title |
Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf] |
| title_short |
Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf] |
| title_full |
Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf] |
| title_fullStr |
Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf] |
| title_full_unstemmed |
Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v1; ref status: indexed, http://f1000r.es/2wf] |
| title_sort |
drugs acting on central nervous system (cns) targets as leads for non-cns targets [v1; ref status: indexed, http://f1000r.es/2wf] |
| publisher |
F1000 Research Ltd |
| series |
F1000Research |
| issn |
2046-1402 |
| publishDate |
2014-02-01 |
| description |
Out-of-the-box approaches are currently needed to replenish the souring pipelines of pharmaceutical companies across the globe. Here a theme is presented – the use of central nervous system (CNS) drugs as leads for non-CNS targets. The approach is related to the use of existing drugs for new indications. Suitable chemical modifications of the CNS drugs abolish their CNS penetration. These novel analogs may then be screened for activity against non-CNS targets. Careful selection of the appropriate structural modifications remains the key to success. |
| topic |
Drug Discovery & Design Neuropharmacology & Psychopharmacology Small Molecule Chemistry |
| url |
http://f1000research.com/articles/3-40/v1 |
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AT prashantskharkar drugsactingoncentralnervoussystemcnstargetsasleadsfornoncnstargetsv1refstatusindexedhttpf1000res2wf |
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