Methylglyoxal Detoxification Revisited: Role of Glutathione Transferase in Model Cyanobacterium Synechocystis sp. Strain PCC 6803

Methylglyoxal Detoxification Revisited: Role of Glutathione Transferase in Model Cyanobacterium Synechocystis sp. Strain PCC 6803

In most organisms, methylglyoxal (MG), a toxic metabolite by-product that causes diabetes in humans, is predominantly detoxified by the glyoxalase enzymes. This process begins with the so-called “spontaneous” conjugation of MG with the cytoprotectant metabolite glutathione (GSH). In this study, we u...

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Bibliographic Details
Main Authors: Xavier Kammerscheit, Arnaud Hecker, Nicolas Rouhier, Franck Chauvat, Corinne Cassier-Chauvat
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
cyanobacteria
detoxification
enzyme assay
glutathione transferase
glyoxalase pathway
in vivo analysis
methylglyoxal
oxidative stress
sugar metabolism
Online Access:https://doi.org/10.1128/mBio.00882-20

Internet

https://doi.org/10.1128/mBio.00882-20

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