H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.

H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.

During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history of recent seasonal trivalent vaccine in younger adults was not associated...

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Bibliographic Details
Main Authors: M Anthony Moody, Ruijun Zhang, Emmanuel B Walter, Christopher W Woods, Geoffrey S Ginsburg, Micah T McClain, Thomas N Denny, Xi Chen, Supriya Munshaw, Dawn J Marshall, John F Whitesides, Mark S Drinker, Joshua D Amos, Thaddeus C Gurley, Joshua A Eudailey, Andrew Foulger, Katherine R DeRosa, Robert Parks, R Ryan Meyerhoff, Jae-Sung Yu, Daniel M Kozink, Brice E Barefoot, Elizabeth A Ramsburg, Surender Khurana, Hana Golding, Nathan A Vandergrift, S Munir Alam, Georgia D Tomaras, Thomas B Kepler, Garnett Kelsoe, Hua-Xin Liao, Barton F Haynes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3198447?pdf=render

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