Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs

Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs

Abstract Background There are over 17,000 patients in the US waiting to receive liver transplants, and these numbers are increasing dramatically. Significant effort is being made to obtain functional hepatocytes and liver tissue that can for therapeutic use in patients. Blastocyst complementation is...

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Main Authors: M. Ruiz-Estevez, A. T. Crane, P. Rodriguez-Villamil, F. L. Ongaratto, Yun You, A. R. Steevens, C. Hill, T. Goldsmith, D. A. Webster, L. Sherry, S. Lim, N. Denman, W. C. Low, D. F. Carlson, J. R. Dutton, C. J. Steer, O. Gafni
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Development
Stem cells
Gene editing
Embryo
Transplantation
Online Access:https://doi.org/10.1186/s13287-021-02348-z

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