Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements

Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site...

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Bibliographic Details
Main Authors: Sen Wu, Marco Mariotti, Didac Santesmasses, Kristina E. Hill, Janinah Baclaocos, Estel Aparicio-Prat, Shuping Li, John Mackrill, Yuanyuan Wu, Michael T. Howard, Mario Capecchi, Roderic Guigó, Raymond F. Burk, John F. Atkins
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
codon redefinition
ribosome specialization
selenocysteine
selenoprotein p
selenoprotein s
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160241

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160241

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