A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds

There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This is achieved by attaching different...

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Main Authors:	Su Ki Liew, Sharan Malagobadan, Norhafiza M. Arshad, Noor Hasima Nagoor
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Biomolecules
Subjects:	substituent synthesis antimetastasis structure-activity relationships biotechnology
Online Access:	https://www.mdpi.com/2218-273X/10/1/138

id	doaj-4d63df00cd6b40a5a82438d49a478cf2
record_format	Article
spelling	doaj-4d63df00cd6b40a5a82438d49a478cf22020-11-25T01:27:39ZengMDPI AGBiomolecules2218-273X2020-01-0110113810.3390/biom10010138biom10010138A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic CompoundsSu Ki Liew0Sharan Malagobadan1Norhafiza M. Arshad2Noor Hasima Nagoor3Institute of Biological Science (Genetics and Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur 50603, MalaysiaInstitute of Biological Science (Genetics and Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur 50603, MalaysiaCentre for Research in Biotechnology for Agriculture (CEBAR), University of Malaya, Kuala Lumpur 50603, MalaysiaInstitute of Biological Science (Genetics and Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur 50603, MalaysiaThere are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This is achieved by attaching different substituents to generate different structure−activity relationships. This review highlights the effectiveness of different functional groups known to have antimigration and antiproliferation activities, such as fluoro, methoxy, methyl, amino, hydroxy, nitro, bromo, chloro, methylamino, ethoxy, carbonyl, iodo, and trifluoromethyl groups. Additionally, the positioning of these functional groups plays an important role in their anticancer activities, which was evident in one of our studies comparing analogues of a natural compound. Thus, this review suggests future recommendations for the design and development of improved anticancer drugs with higher efficacy.https://www.mdpi.com/2218-273X/10/1/138substituentsynthesisantimetastasisstructure-activity relationshipsbiotechnology
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Su Ki Liew Sharan Malagobadan Norhafiza M. Arshad Noor Hasima Nagoor
spellingShingle	Su Ki Liew Sharan Malagobadan Norhafiza M. Arshad Noor Hasima Nagoor A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds Biomolecules substituent synthesis antimetastasis structure-activity relationships biotechnology
author_facet	Su Ki Liew Sharan Malagobadan Norhafiza M. Arshad Noor Hasima Nagoor
author_sort	Su Ki Liew
title	A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds
title_short	A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds
title_full	A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds
title_fullStr	A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds
title_full_unstemmed	A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds
title_sort	review of the structure–activity relationship of natural and synthetic antimetastatic compounds
publisher	MDPI AG
series	Biomolecules
issn	2218-273X
publishDate	2020-01-01
description	There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This is achieved by attaching different substituents to generate different structure−activity relationships. This review highlights the effectiveness of different functional groups known to have antimigration and antiproliferation activities, such as fluoro, methoxy, methyl, amino, hydroxy, nitro, bromo, chloro, methylamino, ethoxy, carbonyl, iodo, and trifluoromethyl groups. Additionally, the positioning of these functional groups plays an important role in their anticancer activities, which was evident in one of our studies comparing analogues of a natural compound. Thus, this review suggests future recommendations for the design and development of improved anticancer drugs with higher efficacy.
topic	substituent synthesis antimetastasis structure-activity relationships biotechnology
url	https://www.mdpi.com/2218-273X/10/1/138
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A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds

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