Wheel-Running Behavior Is Negatively Impacted by Zinc Administration in a Novel Dual Transgenic Mouse Model of AD

Alzheimer’s disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an important role in AD-related pathology. In this study, we show alterations in wheel-running behavior both early and late in disease progression i...

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Bibliographic Details
Main Authors: Stephen L. P. Lippi, Peter A. Kakalec, Meghann L. Smith, Jane M. Flinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
sex
age
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00854/full