Autoantibodies Against C3b—Functional Consequences and Disease Relevance

Autoantibodies Against C3b—Functional Consequences and Disease Relevance

The complement component C3 is at the heart of the complement cascade. It is a complex protein, which generates different functional activated fragments (C3a, C3b, iC3b, C3c, C3d). C3b is a constituent of the alternative pathway C3 convertase (C3bBb), binds multiple regulators, and receptors, affect...

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Bibliographic Details
Main Authors: Vasil V. Vasilev, Maria Radanova, Valentin J. Lazarov, Marie-Agnes Dragon-Durey, Veronique Fremeaux-Bacchi, Lubka T. Roumenina
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
anti-C3 autoantibodies
anti-C3b autoantibodies
complement
immunoconglutinins
autoimmunity
systemic lupus erythematosus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00064/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00064/full

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