α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions

Abstract Background Keratinocytes form the main protective barrier in the skin to separate the underlying tissue from the external environment. In order to maintain this barrier, keratinocytes form robust junctions between neighbouring cells as well as with the underlying extracellular matrix. Cell–...

Full description

Bibliographic Details
Main Authors: Jake D. Howden, Magdalene Michael, Willow Hight-Warburton, Maddy Parsons
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Biology
Subjects:
Online Access:https://doi.org/10.1186/s12915-021-01054-9