Transient Depletion of CD169+ Cells Contributes to Impaired Early Protection and Effector CD8+ T Cell Recruitment against Mucosal Respiratory Syncytial Virus Infection

Transient Depletion of CD169+ Cells Contributes to Impaired Early Protection and Effector CD8+ T Cell Recruitment against Mucosal Respiratory Syncytial Virus Infection

Respiratory syncytial virus (RSV) is a major cause of respiratory viral infections in infants and children. Alveolar macrophages (AMs) play a crucial role in combatting airborne pathogens, strongly express CD169, and are localized in the lung alveoli. Therefore, we used CD169-diphtheria toxin recept...

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Bibliographic Details
Main Authors: Dong Sun Oh, Ji Eun Oh, Hi Eun Jung, Heung Kyu Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
alveolar macrophage
respiratory syncytial virus
type I interferon
CD169
CXCL9/10
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00819/full

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