Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

Connexin 43 (Cx43) widely exists in all components of the neurovascular unit (NVU) and is a constituent of gap junctions and hemichannels. In physiological states, gap junctions are open for regular intercellular communication, and the hemichannels present low open probability in astrocytes. After c...

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Bibliographic Details
Main Authors: Yingzhu Chen, Liangzhu Wang, Lingling Zhang, Beilei Chen, Liu Yang, Xiaobo Li, Yuping Li, Hailong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cerebral ischemia/reperfusion
hemichannel
inflammation
toll-like receptor 4
neurovascular unit
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00372/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00372/full

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