Apoptosis and autophagy in breast cancer cells following exemestane treatment.
Aromatase inhibitors (AIs), which block the conversion of androgens to estrogens, are used for hormone-dependent breast cancer treatment. Exemestane, a steroidal that belongs to the third-generation of AIs, is a mechanism-based inhibitor that binds covalently and irreversibly, inactivating and desta...
Main Authors: | Cristina Amaral, Margarida Borges, Soraia Melo, Elisiário Tavares da Silva, Georgina Correia-da-Silva, Natércia Teixeira |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3418278?pdf=render |
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