The Neuroprotective Effect of Sodium Nitrite on Ischemic Stroke-Induced Mitochondrial Dysfunction via Downregulation of Intrinsic Apoptosis Pathway

The Neuroprotective Effect of Sodium Nitrite on Ischemic Stroke-Induced Mitochondrial Dysfunction via Downregulation of Intrinsic Apoptosis Pathway

Objective: Ischemic stroke leads to programmed cell death via intrinsic mitochondrial apoptosis pathways. Nitric oxide donors (NODs) are various kinds of drugs with the ability to produce nitric oxide (NO) as a potential bioregulator of apoptosis. Therefore, we aimed to evaluate the effect of sodium...

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Bibliographic Details
Main Authors: Mohammad Hasan Khadem Ansari, Pouran Karimi, Nader Shakib, Sohrab Minaei Beyrami
Format: Article
Language:English
Published: Aras Part Medical International Press 2018-01-01
Series:Crescent Journal of Medical and Biological Sciences
Subjects:
Oxygen-glucose deprivation
PC12
Nitrite
Bcl2
Bax
Mitochondria
Online Access:http://cjmb.org/uploads/pdf/pdf_CJMB_62.pdf

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