Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle.

Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle.

Myocilin (MYOC) is the gene with mutations most common in glaucoma. In the eye, MYOC is in trabecular meshwork, ciliary body, and retina. Other tissues with high MYOC transcript levels are skeletal muscle and heart. To date, the function of wild-type MYOC remains unknown and how mutant MYOC causes h...

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Bibliographic Details
Main Authors: Jeffrey M Lynch, Andrew J Dolman, Chenying Guo, Katie Dolan, Chuanxi Xiang, Samir Reda, Bing Li, Ganesh Prasanna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6218065?pdf=render

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