Signal intensities derived from different NMR probes and parameters contribute to variations in quantification of metabolites.

Signal intensities derived from different NMR probes and parameters contribute to variations in quantification of metabolites.

We discovered that serious issues could arise that may complicate interpretation of metabolomic data when identical samples are analyzed at more than one NMR facility, or using slightly different NMR parameters on the same instrument. This is important because cross-center validation metabolomics st...

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Bibliographic Details
Main Authors: Paige Lacy, Ryan T McKay, Michael Finkel, Alla Karnovsky, Scott Woehler, Michael J Lewis, David Chang, Kathleen A Stringer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897511?pdf=render

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