Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment

Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment

A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer...

Full description

Bibliographic Details
Main Authors: Hochung Jang, Eun Hye Kim, Sung-Gil Chi, Sun Hwa Kim, Yoosoo Yang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
nanoparticles
innate immune cells
tumor microenvironment
cancer therapy
Online Access:https://www.mdpi.com/1422-0067/22/18/10009
id doaj-4d25f75c91514076ad6556e4157f97c3
record_format Article
spelling doaj-4d25f75c91514076ad6556e4157f97c32021-09-26T00:24:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122100091000910.3390/ijms221810009Nanoparticles Targeting Innate Immune Cells in Tumor MicroenvironmentHochung Jang0Eun Hye Kim1Sung-Gil Chi2Sun Hwa Kim3Yoosoo Yang4Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, KoreaDepartment of Life Sciences, Korea University, Seoul 02841, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, KoreaA variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.https://www.mdpi.com/1422-0067/22/18/10009nanoparticlesinnate immune cellstumor microenvironmentcancer therapy
collection DOAJ
language English
format Article
sources DOAJ
author Hochung Jang
Eun Hye Kim
Sung-Gil Chi
Sun Hwa Kim
Yoosoo Yang
spellingShingle Hochung Jang
Eun Hye Kim
Sung-Gil Chi
Sun Hwa Kim
Yoosoo Yang
Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
International Journal of Molecular Sciences
nanoparticles
innate immune cells
tumor microenvironment
cancer therapy
author_facet Hochung Jang
Eun Hye Kim
Sung-Gil Chi
Sun Hwa Kim
Yoosoo Yang
author_sort Hochung Jang
title Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
title_short Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
title_full Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
title_fullStr Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
title_full_unstemmed Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
title_sort nanoparticles targeting innate immune cells in tumor microenvironment
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-09-01
description A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.
topic nanoparticles
innate immune cells
tumor microenvironment
cancer therapy
url https://www.mdpi.com/1422-0067/22/18/10009
work_keys_str_mv AT hochungjang nanoparticlestargetinginnateimmunecellsintumormicroenvironment
AT eunhyekim nanoparticlestargetinginnateimmunecellsintumormicroenvironment
AT sunggilchi nanoparticlestargetinginnateimmunecellsintumormicroenvironment
AT sunhwakim nanoparticlestargetinginnateimmunecellsintumormicroenvironment
AT yoosooyang nanoparticlestargetinginnateimmunecellsintumormicroenvironment
_version_ 1717366237049126912

Similar Items