Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma

Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma

The aim of this study is to effectively enhance antitumor activities of endostatin by preparing polymeric nanocarriers. NMR and FT-IR spectra confirmed the successful grafting of the CHT-g-PEI and CHT-g-PEI-PEG-NH2 conjugates. SEM micrographs confirmed the shape of endostatin-loaded nanoparticles to...

Full description

Bibliographic Details
Main Authors:	Samson A. Adeyemi, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Viness Pillay
Format:	Article
Language:	English
Published:	Hindawi Limited 2017-01-01
Series:	Journal of Nanomaterials
Online Access:	http://dx.doi.org/10.1155/2017/2539065

Similar Items

Folate-decorated, endostatin-loaded, nanoparticles for anti-proliferative chemotherapy in esophaegeal squamous cell carcinoma
by: Samson A. Adeyemi, et al.
Published: (2019-11-01)

In Vitro and In Silico Analyses of Nicotine Release from a Gelisphere-Loaded Compressed Polymeric Matrix for Potential Parkinson’s Disease Interventions
by: Pradeep Kumar, et al.
Published: (2018-11-01)

The Influence of Lyophilized EmuGel Silica Microspheres on the Physicomechanical Properties, In Vitro Bioactivity and Biodegradation of a Novel Ciprofloxacin-Loaded PCL/PAA Scaffold
by: Mostafa Mabrouk, et al.
Published: (2016-06-01)

Serum Endostatin Levels in Oral Squamous Cell Carcinoma
by: Maryam Mardani, et al.
Published: (2018-05-01)

An Injectable Nano-Enabled Thermogel to Attain Controlled Delivery of p11 Peptide for the Potential Treatment of Ocular Angiogenic Disorders of the Posterior Segment
by: Lisa Claire du Toit, et al.
Published: (2021-01-01)

A Novel Melt-Dispersion Technique for Simplistic Preparation of Chlorpromazine-Loaded Polycaprolactone Nanocapsules
by: Thiresen Govender, et al.
Published: (2015-06-01)

Neo-Geometric Copper Nanocrystals by Competitive, Dual Surfactant-Mediated Facet Adsorption Controlling Skin Permeation
by: Karmani Murugan, et al.
Published: (2016-11-01)

Artificial, Triple-Layered, Nanomembranous Wound Patch for Potential Diabetic Foot Ulcer Intervention
by: Mostafa Mabrouk, et al.
Published: (2018-10-01)

Macroporous chitosan/methoxypoly(ethylene glycol) based cryosponges with unique morphology for tissue engineering applications
by: Pradeep Kumar, et al.
Published: (2021-02-01)

A symbiotic glance at the complexities of signature microbiomic interventions: Infusing balance
by: Pradeep Kumar, et al.
Published: (2014-11-01)

In Silico Affinity Profiling of Neuroactive Polyphenols for Post-Traumatic Calpain Inactivation: A Molecular Docking and Atomistic Simulation Sensitivity Analysis
by: Pradeep Kumar, et al.
Published: (2014-12-01)

Repositioning <i>N</i>-Acetylcysteine (NAC): NAC-Loaded Electrospun Drug Delivery Scaffolding for Potential Neural Tissue Engineering Application
by: Gillian D. Mahumane, et al.
Published: (2020-09-01)

Nanotechnology and Glycosaminoglycans: Paving the Way Forward for Ovarian Cancer Intervention
by: Yasar Hoosen, et al.
Published: (2018-03-01)

Recombinant Human Endostatin in the Treatment of Advanced Lung Squamous Cell Carcinoma
by: Puyuan XING, et al.
Published: (2016-10-01)

3D Printed, PVA–PAA Hydrogel Loaded-Polycaprolactone Scaffold for the Delivery of Hydrophilic In-Situ Formed Sodium Indomethacin
by: Mershen Govender, et al.
Published: (2018-06-01)

“On-The-Spot” Arresting of Chondroitin Sulphate Proteoglycans: Implications for Ovarian Adenocarcinoma Recognition and Intervention
by: Priyamvada Pradeep, et al.
Published: (2016-07-01)

Hypertension and Antiangiogenesis
by: Rhian M. Touyz, MBBCh, PhD, et al.
Published: (2019-09-01)

In vivo antitumor effect of endostatin-loaded chitosan nanoparticles combined with paclitaxel on Lewis lung carcinoma
by: Fang Xie, et al.
Published: (2017-01-01)

Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention
by: Patrick P. Komane, et al.
Published: (2018-06-01)

In Silico Theoretical Molecular Modeling for Alzheimer’s Disease: The Nicotine-Curcumin Paradigm in Neuroprotection and Neurotherapy
by: Yahya E. Choonara, et al.
Published: (2011-01-01)

Novel High-Viscosity Polyacrylamidated Chitosan for Neural Tissue Engineering: Fabrication of Anisotropic Neurodurable Scaffold via Molecular Disposition of Persulfate-Mediated Polymer Slicing and Complexation
by: Viness Pillay, et al.
Published: (2012-10-01)

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury
by: Poornima Ramburrun, et al.
Published: (2014-01-01)

Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications
by: Mpumelelo Nyoka, et al.
Published: (2020-01-01)

Targeted Delivery of Amantadine-loaded Methacrylate Nanosphere-ligands for the Potential Treatment of Amyotrophic Lateral Sclerosis
by: Zamanzima Mazibuko, et al.
Published: (2018-03-01)

Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications
by: Taskeen Sarwan, et al.
Published: (2020-03-01)

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis
by: Kara M. de la Harpe, et al.
Published: (2019-10-01)

Prolonged Delivery of Ciprofloxacin and Diclofenac Sodium from a Polymeric Fibre Device for the Treatment of Peridontal Disease
by: Deanne Johnston, et al.
Published: (2013-01-01)

A Hybrid Methacrylate-Sodium Carboxymethylcellulose Interpolyelectrolyte Complex: Rheometry and in Silico Disposition for Controlled Drug Release
by: Viness Pillay, et al.
Published: (2013-09-01)

Chemotherapeutic Efficacy of Implantable Antineoplastic-Treatment Protocols in an Optimal Mouse Model for Human Ovarian Carcinoma Cell Targeting
by: Jonathan M. Pantshwa, et al.
Published: (2018-10-01)

Drug Delivery Strategies for Antivirals against Hepatitis B Virus
by: Latavia Singh, et al.
Published: (2018-05-01)

A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery
by: Zaheeda Khan, et al.
Published: (2013-01-01)

IN VITRO ANTIANGIOGENESIS ACTIVITY OF STANDARDIZED EXTRACTS OF Piper sarmentosum Roxb
by: Khalid Hussain, et al.
Published: (2015-02-01)

Functionalized, Vertically Super-Aligned Multiwalled Carbon Nanotubes for Potential Biomedical Applications
by: Patrick P. Komane, et al.
Published: (2020-03-01)

Polymer-Based Nanoparticle Strategies for Insulin Delivery
by: Shazia Mansoor, et al.
Published: (2019-08-01)

Synthesis of benzimidazoles as antiangiogenesis agents
by: Jing-Yan Gao, et al.
Published: (2018)

Monitoring antiangiogenesis of bevacizumab in zebrafish
by: Zhang J, et al.
Published: (2018-08-01)

A Polyvinyl Alcohol-Polyaniline Based Electro-Conductive Hydrogel for Controlled Stimuli-Actuable Release of Indomethacin
by: Pradeep Kumar, et al.
Published: (2011-01-01)

A Mucoadhesive Electrospun Nanofibrous Matrix for Rapid Oramucosal Drug Delivery
by: Clare Dott, et al.
Published: (2013-01-01)

Preparation of endostatin-loaded chitosan nanoparticles and evaluation of the antitumor effect of such nanoparticles on the Lewis lung cancer model
by: Rui-Lin Ding, et al.
Published: (2017-01-01)

Fabrication, Modeling and Characterization of Multi-Crosslinked Methacrylate Copolymeric Nanoparticles for Oral Drug Delivery
by: Riaz A. Khan, et al.
Published: (2011-09-01)