AMPK: Potential Therapeutic Target for Vascular Calcification

AMPK: Potential Therapeutic Target for Vascular Calcification

Vascular calcification (VC) is an urgent worldwide health issue with no available medical treatment. It is an active cell-driven process by osteogenic differentiation of vascular cells with complex mechanisms. The AMP-activated protein kinase (AMPK) serves as the master sensor of cellular energy sta...

Full description

Bibliographic Details
Main Authors:	Yi Lu, Tan Yuan, Xinjia Min, Zhen Yuan, Zhejun Cai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	AMP-activated protein kinase autophagy endoplasmic reticulum stress runt-related transcription factor 2 vascular calcification
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2021.670222/full

Similar Items

Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification
by: Hui Li, et al.
Published: (2017-09-01)

Vascular Calcification—New Insights Into Its Mechanism
by: Sun Joo Lee, et al.
Published: (2020-04-01)

A novel role of cellular interactions in vascular calcification
by: Adham Sameer A. Bardeesi, et al.
Published: (2017-05-01)

<i>Poria cocus</i> Wolf Extract Ameliorates Hepatic Steatosis through Regulation of Lipid Metabolism, Inhibition of ER Stress, and Activation of Autophagy via AMPK Activation
by: Ji-Hyun Kim, et al.
Published: (2019-09-01)

Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells
by: Qi Liu, et al.
Published: (2022-02-01)

The Targeting of Autophagy and Endoplasmic Reticulum Stress Mechanisms by Honokiol Therapy
by: Zahra Ahmadi, et al.
Published: (2019-06-01)

The Protective Effects of the Autophagic and Lysosomal Machinery in Vascular and Valvular Calcification: A Systematic Review
by: Cédric H. G. Neutel, et al.
Published: (2020-11-01)

Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK
by: Jinmi Lee, et al.
Published: (2015-06-01)

Therapeutic approaches targeting endoplasmic reticulum stress in diabetic endothelial dysfunction.
Published: (2014)

Role of Glycosylation in Vascular Calcification
by: Ainun Nizar Masbuchin, et al.
Published: (2021-09-01)

Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification
by: Soeiro A, et al.
Published: (2011-03-01)

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy
by: Ming Yang, et al.
Published: (2020-07-01)

Bone metabolism and vascular calcification
by: C.F. Danilevicius, et al.
Published: (2007-04-01)

The Thermodynamics of Medial Vascular Calcification
by: Ángel Millán, et al.
Published: (2021-04-01)

Multiple functions of autophagy in vascular calcification
by: Xin Zhou, et al.
Published: (2021-08-01)

The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective
by: Yi-Chou Hou, et al.
Published: (2020-02-01)

Calciprotein Particles and Serum Calcification Propensity: Hallmarks of Vascular Calcifications in Patients with Chronic Kidney Disease
by: Ciprian N. Silaghi, et al.
Published: (2020-04-01)

Bavachin Protects Human Aortic Smooth Muscle Cells Against β-Glycerophosphate-Mediated Vascular Calcification and Apoptosis via Activation of mTOR-Dependent Autophagy and Suppression of β-Catenin Signaling
by: Hu-Qiang He, et al.
Published: (2019-12-01)

The Therapeutic Effect of Melatonin on GC by Inducing Cell Apoptosis and Autophagy Induced by Endoplasmic Reticulum Stress
by: Zheng Y, et al.
Published: (2019-11-01)

Reticulon Homology Domain-Containing Proteins and ER-Phagy
by: Manuela D’Eletto, et al.
Published: (2020-02-01)

Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum
by: Yiqi Wang, et al.
Published: (2021-11-01)

A guide to understanding endoplasmic reticulum stress in metabolic disorders
by: Imke L. Lemmer, et al.
Published: (2021-05-01)

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
by: Paolo Grumati, et al.
Published: (2017-06-01)

Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis
by: Dan Qiao, et al.
Published: (2021-09-01)

Research Models for Studying Vascular Calcification
by: Jaqueline Herrmann, et al.
Published: (2020-03-01)

Protein kinase-like ER kinase (PERK) regulates autophagy of hemocytes in antiviral immunity of Pacific oyster Crassostrea gigas
by: Shujing Liu, et al.
Published: (2020-12-01)

Vascular calcification: the role of microRNAs
by: Alkagiet Stelina, et al.
Published: (2017-05-01)

Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment
by: He Y, et al.
Published: (2019-03-01)

Comparing the Role of Mechanical Forces in Vascular and Valvular Calcification Progression
by: Madeleine A. Gomel, et al.
Published: (2019-01-01)

Effects of homocysteine-induced endoplasmic reticulum protein on endoplasmic reticulum stress, autophagy, and neuronal apoptosis following intracerebral hemorrhage
by: Hui Wu, et al.
Published: (2020-12-01)

Extensive vascular calcification
by: Mukesh Dhillon, et al.
Published: (2015-01-01)

Vascular and Valvular Calcifications in Chronic Kidney Disease: An Update
by: Luca Di Lullo, et al.
Published: (2016-07-01)

IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis
by: Zihao Li, et al.
Published: (2021-06-01)

Low Muscle Mass in Patients Receiving Hemodialysis: Correlations with Vascular Calcification and Vascular Access Failure
by: Seok-hyung Kim, et al.
Published: (2021-08-01)

5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications
by: Fan Yao, et al.
Published: (2016-01-01)

Predictive Value of Measures of Vascular Calcification Burden and Progression for Risk of Death in Incident to Dialysis Patients
by: Antonio Bellasi, et al.
Published: (2021-01-01)

Vascular Calcification in Chronic Kidney Disease: An Update
by: Mario Cozzolino, et al.
Published: (2013-07-01)

Haemodialysis session: The perfect storm for vascular calcification
by: Miguel Seras, et al.
Published: (2015-09-01)

Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients
by: Tarek Z. El Baz, et al.
Published: (2017-06-01)

The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments
by: SEYED SHOBEIRI, NAVID
Published: (2013)