Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke

Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke

Stroke is one of the major culprits responsible for morbidity and mortality worldwide, and the currently available pharmacological strategies to combat this global disease are scanty. Cation-chloride cotransporters (CCCs) are expressed in several tissues (including neurons) and extensively contribut...

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Bibliographic Details
Main Authors: Sunday Solomon Josiah, Nur Farah Azlan Meor, Jinwei Zhang
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
stroke
electroneutral transport
cation-chloride cotransporters
KCCs
NKCCs
WNK-SPAK/OSR1
Online Access:https://www.mdpi.com/1422-0067/22/3/1232

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