Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil

Dynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The str...

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Bibliographic Details
Main Authors: Yan Zhang, Chi-Yen Pham, Rui Yu, Eddy Petit, Suming Li, Mihail Barboiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00739/full