Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat model

Abstract Background Knowledge regarding the pathogenesis of osteoarthritis (OA) is very limited. Previous studies have shown that matrix metalloproteinase (MMP) 8 and MMP9 were upregulated in patients with diabetic OA. However, their regulatory functions and mechanisms in diabetic OA are not fully u...

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Bibliographic Details
Main Authors: Simin Luo, Wuji Li, Wenrui Wu, Qiping Shi
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-021-02208-9