GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

Transcriptional repression needs to be rapidly reversible during embryonic development. This extends to the Hedgehog pathway, which primarily serves to counter GLI repression by processing GLI proteins into transcriptional activators. In investigating the mechanisms underlying GLI repression, we fin...

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Bibliographic Details
Main Authors: Rachel K Lex, Zhicheng Ji, Kristin N Falkenstein, Weiqiang Zhou, Joanna L Henry, Hongkai Ji, Steven A Vokes
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
Hedgehog
transcriptional repression
GLI
enhancers
chromatin
limb bud
Online Access:https://elifesciences.org/articles/50670

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