Stabilization of the Penicillium chrysogenum strain with pelletized morphological structure by selection, multiplication, and control of the variability of pure cultures
This study showed that Penicillium chrysogenum exhibits during submerged cultivation two distinct features: a filamentous structure characterized by long, branched, loose hyphae, and a pelletized morphological structure characterized by short, thickened hyphae clustered in a glomerule-like formation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Alexandru Ioan Cuza" University of Iași
2008-05-01
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| Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
| Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/665 |
| Summary: | This study showed that Penicillium chrysogenum exhibits during submerged cultivation two distinct features: a
filamentous structure characterized by long, branched, loose hyphae, and a pelletized morphological structure
characterized by short, thickened hyphae clustered in a glomerule-like formation called pellet. With a view to maintaining
the potential to biosynthesize the pelletized strain penicillin to a maximum, the operations involving the selection,
multiplication and variability control of pure culture should be conducted periodically to prevent phenotypic and
genotypic deviations to parental forms. |
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| ISSN: | 1582-3571 2248-3276 |