Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro

Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro

High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration of high doses of IL2 can be toxic, causing capillary leakage syndrome and stimulating pro-tumor immune response. One of the strategies t...

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Bibliographic Details
Main Authors: Daria S. Chulpanova, Valeriya V. Solovyeva, Victoria James, Svetlana S. Arkhipova, Marina O. Gomzikova, Ekaterina E. Garanina, Elvira R. Akhmetzyanova, Leysan G. Tazetdinova, Svetlana F. Khaiboullina, Albert A. Rizvanov
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Bioengineering
Subjects:
immunotherapy
mesenchymal stem cells
interleukin 2
cancer therapy
neuroblastoma
Online Access:https://www.mdpi.com/2306-5354/7/2/59

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