Synthesis of heterocyclic compounds and its applications

• Main Authors: Mohan N. Patel, Parag S. Karia, Pankajkumar A. Vekariya, Anshul P. Patidar
• Format: Article
• Language: English
• Published: Elsevier 2019-12-01
• Series: Arabian Journal of Chemistry
• Online Access: http://www.sciencedirect.com/science/article/pii/S1878535215002038
• ISSN: 1878-5352

The octahedral ruthenium(II) complexes [Ru(Ln)(PPh3)2Cl2] [Ln = biphenyl furanyl pyridine derivatives] were synthesized and characterized using LC–MS, IR spectroscopy, elemental analysis and magnetic measurements. Complexes show enhancement in antibacterial activity compared to free ligands. From the binding mode investigation by absorption titration and viscosity measurement, it is observed that complexes bind to DNA via intercalation and also complexes promote the cleavage of supercoiled pUC19 plasmid DNA. Cytotoxicity analysis shows 100% mortality of Brine shrimp after 48 h. Keywords: Heterocyclic compound, Ruthenium(II) complexes, Nucleic acid intercalating agent, Cytotoxicity