Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain.
Spinal muscular atrophy (SMA) is a leading genetic cause of childhood mortality, caused by reduced levels of survival motor neuron (SMN) protein. SMN functions as part of a large complex in the biogenesis of small nuclear ribonucleoproteins (snRNPs). It is not clear if defects in snRNP biogenesis ca...
Main Authors: | Jennifer L Fuentes, Molly S Strayer, A Gregory Matera |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-12-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3012718?pdf=render |
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