Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain.

Spinal muscular atrophy (SMA) is a leading genetic cause of childhood mortality, caused by reduced levels of survival motor neuron (SMN) protein. SMN functions as part of a large complex in the biogenesis of small nuclear ribonucleoproteins (snRNPs). It is not clear if defects in snRNP biogenesis ca...

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Bibliographic Details
Main Authors: Jennifer L Fuentes, Molly S Strayer, A Gregory Matera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012718?pdf=render

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