Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity

Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary trac...

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Main Authors:	Ali M. Al-joda, Munaf H. Zalzala
Format:	Article
Language:	English
Published:	College of Pharmacy University of Baghdad 2019-12-01
Series:	Iraqi Journal of Pharmaceutical Sciences
Online Access:	http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/960

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spelling	doaj-4cf535260abd440f9602d439ef6dd7692020-11-25T02:22:03ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972019-12-0128218018510.31351/vol28iss2pp180-185960Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal ToxicityAli M. Al-jodaMunaf H. ZalzalaCyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary tract cells. Guggulsterone is a sterol derived from plant has ability to bind to farsenoid X receptor, mineral corticosteroid receptor, androgen receptor, glucocorticoid receptor and estrogen receptor.http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/960
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ali M. Al-joda Munaf H. Zalzala
spellingShingle	Ali M. Al-joda Munaf H. Zalzala Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity Iraqi Journal of Pharmaceutical Sciences
author_facet	Ali M. Al-joda Munaf H. Zalzala
author_sort	Ali M. Al-joda
title	Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity
title_short	Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity
title_full	Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity
title_fullStr	Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity
title_full_unstemmed	Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity
title_sort	inhibition of nf-kb pathway by gggulsterone in the protective effects of cyclophosphamide-induced renal toxicity
publisher	College of Pharmacy University of Baghdad
series	Iraqi Journal of Pharmaceutical Sciences
issn	2521-3512 1683-3597
publishDate	2019-12-01
description	Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary tract cells. Guggulsterone is a sterol derived from plant has ability to bind to farsenoid X receptor, mineral corticosteroid receptor, androgen receptor, glucocorticoid receptor and estrogen receptor.
url	http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/960
work_keys_str_mv	AT alimaljoda inhibitionofnfkbpathwaybygggulsteroneintheprotectiveeffectsofcyclophosphamideinducedrenaltoxicity AT munafhzalzala inhibitionofnfkbpathwaybygggulsteroneintheprotectiveeffectsofcyclophosphamideinducedrenaltoxicity
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Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity

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