Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity

Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary trac...

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Bibliographic Details
Main Authors: Ali M. Al-joda, Munaf H. Zalzala
Format: Article
Language:English
Published: College of Pharmacy University of Baghdad 2019-12-01
Series:Iraqi Journal of Pharmaceutical Sciences
Online Access:http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/960
Description
Summary:Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary tract cells. Guggulsterone is a sterol derived from plant has ability to bind to farsenoid X receptor, mineral corticosteroid receptor, androgen receptor, glucocorticoid receptor and estrogen receptor.
ISSN:2521-3512
1683-3597