Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity
Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary trac...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacy University of Baghdad
2019-12-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/960 |
| Summary: | Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary tract cells. Guggulsterone is a sterol derived from plant has ability to bind to farsenoid X receptor, mineral corticosteroid receptor, androgen receptor, glucocorticoid receptor and estrogen receptor. |
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| ISSN: | 2521-3512 1683-3597 |