PhenCards: a data resource linking human phenotype information to biomedical knowledge

Abstract We present PhenCards ( https://phencards.org ), a database and web server intended as a one-stop shop for previously disconnected biomedical knowledge related to human clinical phenotypes. Users can query human phenotype terms or clinical notes. PhenCards obtains relevant disease/phenotype...

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Bibliographic Details
Main Authors: James M. Havrilla, Cong Liu, Xiangchen Dong, Chunhua Weng, Kai Wang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Medicine
Subjects:
Online Access:https://doi.org/10.1186/s13073-021-00909-8
Description
Summary:Abstract We present PhenCards ( https://phencards.org ), a database and web server intended as a one-stop shop for previously disconnected biomedical knowledge related to human clinical phenotypes. Users can query human phenotype terms or clinical notes. PhenCards obtains relevant disease/phenotype prevalence and co-occurrence, drug, procedural, pathway, literature, grant, and collaborator data. PhenCards recommends the most probable genetic diseases and candidate genes based on phenotype terms from clinical notes. PhenCards facilitates exploration of phenotype, e.g., which drugs cause or are prescribed for patient symptoms, which genes likely cause specific symptoms, and which comorbidities co-occur with phenotypes.
ISSN:1756-994X