Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

Abstract The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm, and cellular models of mitochondrial disease, via an unclear mechanism. Here, we show that prolonged rapamycin treatment improved motor endurance, corrected morphological abnormalities of muscle,...

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Main Authors: Gabriele Civiletto, Sukru Anil Dogan, Raffaele Cerutti, Gigliola Fagiolari, Maurizio Moggio, Costanza Lamperti, Cristiane Benincá, Carlo Viscomi, Massimo Zeviani
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
lysosomal biogenesis
mitochondrial disease
mTORC1
rapamycin
Online Access:https://doi.org/10.15252/emmm.201708799

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