Assessment of Tissue Distribution and Metabolism of MP1, a Novel Pyrrolomycin, in Mice Using a Validated LC-MS/MS Method

Assessment of Tissue Distribution and Metabolism of MP1, a Novel Pyrrolomycin, in Mice Using a Validated LC-MS/MS Method

MP1 is a novel marinopyrrole analogue with activity in MYCN amplified neuroblastoma cell lines. A rapid, selective, and sensitive liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantitation of MP1 in mouse plasma. Analyte separation was...

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Bibliographic Details
Main Authors: Wafaa N. Aldhafiri, Yashpal S. Chhonker, Yuning Zhang, Don W. Coutler, Timothy R. McGuire, Rongshi Li, Daryl J. Murry
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
pyrrolomycin
in-vitro metabolism
LC-MS/MS
biodistribution
Online Access:https://www.mdpi.com/1420-3049/25/24/5898

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