Intrauterine Exposure to Cadmium Reduces HIF-1 DNA-Binding Ability in Rat Fetal Kidneys

Intrauterine Exposure to Cadmium Reduces HIF-1 DNA-Binding Ability in Rat Fetal Kidneys

During embryonic development, some hypoxia occurs due to incipient vascularization. Under hypoxic conditions, gene expression is mainly controlled by hypoxia-inducible factor 1 (HIF-1). The activity of this transcription factor can be altered by the exposure to a variety of compounds; among them is...

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Bibliographic Details
Main Authors: Tania Jacobo-Estrada, Mariana Cardenas-Gonzalez, Mitzi Paola Santoyo-Sánchez, Frank Thevenod, Olivier Barbier
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Toxics
Subjects:
cadmium
embryonic kidneys
HIF-1
intrauterine exposure
Online Access:http://www.mdpi.com/2305-6304/6/3/53

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