The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence
Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometri...
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MDPI AG
2017-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/18/6/1305 |
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doaj-4cc98653dde94878a50def49baa06b472020-11-25T01:42:32ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-06-01186130510.3390/ijms18061305ijms18061305The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical EvidenceAntonis Makrigiannakis0Thomas Vrekoussis1Emmanouel Zoumakis2Sophia N. Kalantaridou3Udo Jeschke4Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion 71003, GreeceDepartment of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina 45110, GreeceDepartment of Pediatrics, Medical School, University of Athens, Athens 11527, GreeceSecond Department of Obstetrics and Gynecology, Medical School, University of Athens, Athens 11528, GreeceDepartments of Obstetrics and Gynecology, Medical School, Ludwig-Maximilians University of Munich, Campus Innenstadt & Campus Grosshadern, Munich 80337, GermanyEmbryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometrial receptivity. Herein, a brief overview of the molecular mechanisms regulated by HCG is presented. Furthermore, we summarize the existing evidence regarding the clinical impact on reproductive outcomes after endometrial priming with HCG prior to embryo transfer. Although promising, further evidence is needed to clarify the protocol that would lead to beneficial outcomes.http://www.mdpi.com/1422-0067/18/6/1305human chorionic gonadotropin (HCG)implantationinfertility |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Antonis Makrigiannakis Thomas Vrekoussis Emmanouel Zoumakis Sophia N. Kalantaridou Udo Jeschke |
| spellingShingle |
Antonis Makrigiannakis Thomas Vrekoussis Emmanouel Zoumakis Sophia N. Kalantaridou Udo Jeschke The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence International Journal of Molecular Sciences human chorionic gonadotropin (HCG) implantation infertility |
| author_facet |
Antonis Makrigiannakis Thomas Vrekoussis Emmanouel Zoumakis Sophia N. Kalantaridou Udo Jeschke |
| author_sort |
Antonis Makrigiannakis |
| title |
The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence |
| title_short |
The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence |
| title_full |
The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence |
| title_fullStr |
The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence |
| title_full_unstemmed |
The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence |
| title_sort |
role of hcg in implantation: a mini-review of molecular and clinical evidence |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2017-06-01 |
| description |
Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometrial receptivity. Herein, a brief overview of the molecular mechanisms regulated by HCG is presented. Furthermore, we summarize the existing evidence regarding the clinical impact on reproductive outcomes after endometrial priming with HCG prior to embryo transfer. Although promising, further evidence is needed to clarify the protocol that would lead to beneficial outcomes. |
| topic |
human chorionic gonadotropin (HCG) implantation infertility |
| url |
http://www.mdpi.com/1422-0067/18/6/1305 |
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