Analysis of atrial remodeling, fibrosis, oxidative stress and insulin resistance levels in patients with atrial fibrillatio
Objective: To investigate the analysis of atrial remodeling, fibrosis, oxidative stress and insulin resistance levels in patients with atrial fibrillation. Methods: 60 patients with atrial fibrillation treated in our hospital from December 2016 to January 2018 were selected as observation group,...
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2019-02-01
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| Series: | Journal of Hainan Medical University |
| Online Access: | http://www.hnykdxxb.com/PDF/201903/13.pdf |
| Summary: | Objective: To investigate the analysis of atrial remodeling, fibrosis, oxidative stress and insulin
resistance levels in patients with atrial fibrillation. Methods: 60 patients with atrial fibrillation
treated in our hospital from December 2016 to January 2018 were selected as observation
group, and 60 healthy persons in the same period were selected as control group. The
expression levels of indexes in atrial remodeling [including osteoprotegerin (OPG), nuclear
factor kappa beta receptor activating factor ligand (RANKL)], fibrosis [including transforming
growth factor beta (TGF-beta) and tumor necrosis factor alpha (TNF-alpha)], oxidative
stress [including reactive oxygen species (ROS) and advanced oxidation protein products
(AOPP)] and insulin resistance [including human fibroblast growth factor -21 (FGF-21) and
omentin-1 (Omentin-1)] were observed and compared between the two groups. Results: The
level of Omentin-1 in observation group [(36.75±4.60) ug/L] was significantly lower than
that in control group [(87.98±4.43) ug/L] (P<0.05). And there was no significant difference
in AOPP level between the observation group and the control group [(13.75±2.13) micromol/
L] (P>0.05). While the levels of atrial remodeling and fibrosis related indexes, ROS and FGF-
21 in the observation group were significantly higher than those in the control group (P<0.05).
Conclusions: Understanding the mechanism of atrial remodeling in patients with atrial
fibrillation contributes to the prevention and treatment of atrial fibrillation. Patients with atrial
fibrillation are not only prone to myocardial fibrosis, but also to oxidative stress and insulin
resistance. The relevant indicators should be strengthened in clinical practice, so as to provide
evidence for early diagnosis and treatment of the disease. |
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| ISSN: | 1007-1237 1007-1237 |