The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level

The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level

Summary: Balanced stem cell self-renewal and differentiation is essential for maintaining tissue homeostasis, but the underlying mechanisms are poorly understood. Here, we identified the transcription factor SRY-related HMG-box (Sox) 100B, which is orthologous to mammalian Sox8/9/10, as a common tar...

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Bibliographic Details
Main Authors: Zhen Jin, Jun Chen, Huanwei Huang, Jiawen Wang, Jiaying Lv, Menghan Yu, Xingting Guo, Yongchao Zhang, Tao Cai, Rongwen Xi
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
intestinal epithelium
cell fate determination
tissue-damage
recovery
dosage-dependent
dosage effect
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306367

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http://www.sciencedirect.com/science/article/pii/S2211124720306367

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